منابع مشابه
TERRA Incognita at chromosome ends.
Telomeres are transcribed in long noncoding RNA named TERRA. Although TERRA functions have been extensively investigated, the role of TERRA in telomerase recruitment and regulation is still elusive. In this issue of EMBO Reports, Moravec et al report in Schizosaccharomyces pombe that telomere shortening induces the expression of TERRA [1]. They show that polyadenylated TERRA molecules specifica...
متن کاملRetrotransposons that maintain chromosome ends.
Reverse transcriptases have shaped genomes in many ways. A remarkable example of this shaping is found on telomeres of the genus Drosophila, where retrotransposons have a vital role in chromosome structure. Drosophila lacks telomerase; instead, three telomere-specific retrotransposons maintain chromosome ends. Repeated transpositions to chromosome ends produce long head to tail arrays of these ...
متن کاملSTN1 protects chromosome ends in Arabidopsis thaliana.
Telomeres shield the natural ends of chromosomes from nucleolytic attack, recognition as double-strand breaks, and inappropriate processing by DNA repair machinery. The trimeric Stn1/Ten1/Cdc13 complex is critical for chromosome end protection in Saccharomyces cerevisiae, while vertebrate telomeres are protected by shelterin, a complex of six proteins that does not include STN1 or TEN1. Recent ...
متن کاملSgs1 and Exo1 suppress targeted chromosome duplication during ends-in and ends-out gene targeting.
Gene targeting is extremely efficient in the yeast Saccharomyces cerevisiae. It is performed by transformation with a linear, non-replicative DNA fragment carrying a selectable marker and containing ends homologous to the particular locus in a genome. However, even in S. cerevisiae, transformation can result in unwanted (aberrant) integration events, the frequency and spectra of which are quite...
متن کاملChromosome ends in Drosophila without telomeric DNA sequences.
We have recovered terminal chromosome deletions of the X chromosome of Drosophila [Df(1)RT; RT = receding tips] that break in various positions of the yellow gene (y) region and delete all distal DNA sequences. Terminal DNA fragments are heterogeneous in length. Molecular cloning and sequencing of the terminal DNA fragments revealed that the broken ends of the deleted chromosomes do not carry a...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1943
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.29.1.1